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KMID : 0374019960190020221
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Ewha Medical Journal
1996 Volume.19 No. 2 p.221 ~ p.226
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Striatal Network Model in Parkinson Disease -Preliminary Study-
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Abstract
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Objective:
@EN To construct the neural network model in the striatum that can explain the clinical
effect of Parkinson disease.
@ES Methods:
@EN We use an approach to studying the function of neural systems that is based on the
use of a class of computer models kown as parallel distributed processors(PDPs). And the
focus of this study is the nigrostriataldopaminergic effects on the corticostriatal fibers and the
striatal medium spiny neurons.
@ES Results:
@EN A model that explains hypokinesia in Parkinson disease is presented for the operation of
the striatum.
@ES Conclusions:
@EN In order to study the brain funcion and mechanism of physiopathology, testable theories
that consider brain as a whole system are needed. We think neural network model with PDPs
would be an important field in neuroscience in a near future.
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KEYWORD
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